$149.99
A critical dinucleotide coenzyme that activates sirtuins and supports mitochondrial function, studied for cellular energy metabolism in research models.
NAD+ is the essential substrate for sirtuins (SIRT1-7), a family of enzymes that regulate aging, inflammation, stress resistance, and metabolism. Without adequate NAD+, sirtuin activity declines, accelerating cellular aging.
NAD+ fuels poly-ADP-ribose polymerases (PARPs), enzymes critical for detecting and repairing DNA damage. Adequate NAD+ helps maintain genomic integrity and cellular health throughout aging.
NAD+ is essential for the electron transport chain in mitochondria, the cellular powerhouses that generate ATP. Declining NAD+ impairs energy production and contributes to age-related fatigue and dysfunction.
Key insight: NAD+ decline creates a 'pseudohypoxic' state that disrupts mitochondrial-nuclear communication
Common questions about NAD+
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every cell of your body. It's essential for over 500 enzymatic reactions, including energy production in mitochondria, DNA repair via PARPs, and activation of longevity-related sirtuins. NAD+ levels naturally decline with age — by up to 50% between ages 40-60 — contributing to metabolic dysfunction and age-related conditions.
IV NAD+ delivers the coenzyme directly into your bloodstream with 100% bioavailability, bypassing digestive metabolism. Oral precursors like NMN and NR must be absorbed and converted into NAD+ through enzymatic pathways, with variable efficiency. IV administration provides immediate cellular access, though it requires clinical administration and is more time-intensive.
A 2022 study of 1,518 participants found that blood NAD+ levels significantly decline with age, particularly in men. The average whole blood NAD+ was 33.0 μmol/L, with men showing higher levels than women (34.5 vs 31.3 μmol/L). Significant decline was observed in the 40-49 age group, becoming more pronounced after age 60. This research supports the hypothesis that declining NAD+ contributes to aging processes.
NAD+ infusions typically last 2-6 hours depending on the dose (500mg-1000mg). Common experiences include temporary nausea, flushing, chest tightness, or cramping — these are usually managed by slowing the infusion rate. Most people feel energized after the session. Side effects generally diminish with subsequent treatments as tolerance develops.
NAD+ research has focused on age-related decline, metabolic dysfunction, and cellular energy support. Those interested typically include adults concerned about aging, individuals seeking to support mitochondrial function, and those looking to complement healthy lifestyle practices. NAD+ therapy should be discussed with a healthcare provider to determine appropriateness for individual circumstances.
Lyophilized (powder) NAD+ should be stored at -20°C, protected from light and moisture. Once reconstituted, solutions should be used promptly and kept refrigerated if not used immediately. NAD+ is sensitive to heat, light, and pH extremes. Proper handling and storage are essential to maintain potency and safety.
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